Validations Request APHP: High Pressure Unreinforced Silicone Tubing

Translucent, Platinum-Cured

high pressure burst testAdvantaSil® High Pressure silicone tubing is a high quality, cost effective solution designed for increased flow rates to reduce your processing time. AdvantaSil High Pressure is the optimal choice for Single-Use applications such as TFF, virus filtration, inline integrity testing of filtration assemblies, and high volume fluid transfer.

AdvantaSil High Pressure tubing has undergone extensive physical, chemical and biological testing and meets USP Class VI, FDA CFR 177.2600, ISO 10993, European Pharmacopoeia 3.1.9 and other standards. Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab. AdvantaSil High Pressure tubing is not intended for implantation or continuous steam applications.


    • Animal Derived Ingredient FreeHight Pressure Tubing
    • Allows for processing at higher flow rates
    • Full vacuum capabilities on most sizes
    • Flexible and translucent yet durable
    • Eliminates particulate shedding that can occur when cutting braid reinforced hose
    • Certified free of animal-derived ingredients
    • General temperature range: -65°F (-53.9°C) to 400°F (204.4°C)
    • Resists temperature extremes, compression set, chemical attack, ozone, radiation, moisture and environmental exposure
    • Sterilizable by autoclave or gamma radiation
    • Available with validated sterility assurance of 10-6 via gamma irradiation per ISO 11137 method VDmax 25
    • Documented lot traceable with identification on bags
    • Documented quality control per ISO 9001:2015
    • Included in our Rx-360 Joint Audit Program for Single-Use Systems
    • Complete validation package available upon request
    • Now available as mini and standard Tri-Clamp® ends — call for details!

Full BPOG standardized extractables test results available on request



cutting APHP tubing




Specific cutting techniques are strongly recommended for AdvantaSil APHP High Pressure Silicone Tubing. APHP must be cut with a chevron style cutter at a 90 degree angle to the tubing, leaving a smooth, non-jagged, perpendicular cut at the tubing end. View cutter product details and purchase information at See our cutting technique video below.






Dimensional Specifications

Product Number Nominal I.D. Wall O.D. Bend Radius Standard Available Lengths
(in.) (mm) (in.) (mm) (in.) (mm) (in.) (mm) (ft.)
APHP-0125-0250 .125 3.18 .063 1.60 .250 6.35 .375 9.5 50
APHP-0250-0375 .250 6.35 .063 1.60 .375 9.52 1 25 50
APHP-0375-0625 .375 9.52 .125 3.18 .625 15.88 1.2 30 50
APHP-0500-0750 .500 12.70 .125 3.18 .750 19.05 1.8 46 50
APHP-0750-1000 .750 19.05 .125 3.18 1.000 25.40 2.1 53 50
APHP-1000-1375 1.000 25.40 .188 4.76 1.375 34.93 4.1 104 50
APHP-1500-1875 1.500 38.1 .188 4.76 1.875 47.6 6 152 10

Performance Specifications

Product Number Burst Pressure Non-Treated Recommended
Working Pressure
based on 3:1 safety factor
Burst Pressure Gamma Irradiated 45kGy  
Recommended Working Pressure
based on 3:1 safety factor
Gamma Irradiated 45kGy
Vacuum Capability
(psi) (bar) (psi) (bar) (psi) (bar) (psi) (bar) (in./Hg)
APHP-0125-0250 175 12.1 58 4.0 184 12.7 61 12.7 >29.5
APHP-0250-0375 109 7.5 36 2.5 127 8.8 42 2.9 >29.5
APHP-0375-0625 168 11.6 56 3.9 182 12.5 61 4.2 >29.5
APHP-0500-0750 124 8.5 41 2.8 138 9.5 46 3.2 >29.5
APHP-0750-1000 103 7.1 34 2.3 113 7.8 38 2.6 >29.5
APHP-1000-1375 76 5.2 25 1.7 105 7.2 35 2.4 >29.5
APHP-1500-1875 83 5.7 27 1.9 91 6.3 30 2.1 >29.5

Sold by standard coil length of 50 ft. Add length suffix code "L" to product number when ordering. Example: 50 ft. of .250 in. I.D. x .375 in. O.D. tubing is product number APHP-0250-0375L.

Non-listed sizes and custom lengths available by special order.

Coils are supplied double bagged in heat-sealed polybags and bulk packed.

Contact your AdvantaPure Sales Representative regarding any special product or packaging needs.

Recommended working pressures are calculated from burst testing using a 3:1 safety factor. Testing was performed at ambient temperature. Application testing is recommended.

CF = Consult factory

The 1.5” APHP is compatible with Abec Bioreactors , CPC Aspectic Connectors , and T and Y Connectors from Nordson

NOTE: The data listed throughout this web site is meant only as a guide to aid in design, and is believed to be reliable; however, nothing stated shall constitute a guarantee or warranty for any application. Product field-testing should be performed to find the actual values for a specific application.


This case study describes the performance of AdvantaSil High Pressure Unreinforced Silicone Tubing (APHP) used in a Monoclonal Antibody process for the transfer of buffers in purification.


PDF Download a printable version of our High Pressure Tubing brochure. AdvantaSil_High_Pressure_Tubing.pdf (163kb)

PDF Click to download a printable PDF version of our AdvantaSil catalog. AdvantaSil_catalog.pdf  (2.7MB)


High Pressure Silicone Tubing

Made in USA


This case study describes the performance of AdvantaSil High Pressure Unreinforced Silicone Tubing (APHP) used in a Monoclonal Antibody process for the transfer of buffers in purification.



single-use systems

Single-use Systems are custom made using AdvantaSil® platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing. Add fittings, stoppers and container closures, filters, bottles, labels and tracking options, and other components.


AdvantaSil silicone tubing and hose

Platinum-Cured Silicone Tubing and Hose

AdvantaSil tubing and hose

The AdvantaSil® family of high purity products include:

• Unreinforced Tubing • Braid Reinforced Hoses • Pump Grade Tubing • Wire Reinforced Suction/Discharge Hoses


Case Studies