AdvantaFlex®: Biopharmaceutical Grade TPE Tubing

Sterile Weldable, Heat Sealable Bioprocess Tubing

AdvantaFlex addresses the
need for a flexible, translucent, sterilizable, moldable, heat-sealable, and weldable biopharmaceutical
tubing for fluid processing. AdvantaFlex TPE tubing maintains its physical properties following
sterilization processes, resists kinking, remains translucent for visible product flow, and does not become gummy.
Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab.

KEY FEATURES

Sterile weldable and heat sealable
Available as leak-proof molded connections and
tubing
Made from FDA-approved ingredients
Certified free of silicone oils and animal-derived ingredients
Sterilizable by autoclave or gamma radiation
Available with validated sterility assurance of 10^-6 via gamma irradiation
per ISO 11137 method VDmax 25
Meets various ISO and USP standards, including Class VI
Meets European Pharmacopoeia 3.2.9 standards
REACH, RoHS, and California Proposition 65 compliant
Excellent low absorption and adsorption characteristics as compared to silicone
Low permeability as compared to silicone
Smooth interior for excellent flow and performance
Translucent for fluid flow visibility
Excellent tubing component for Single-Use systems
Sizes from 1/8″ (.125) through 1″ (1.000) I.D.
Custom lengths, sizes, and packaging available
Supplied double bagged; sealed in polybags at manufacture for cleanliness
Documented lot traceable with identification on packaging
Documented quality control per ISO 9001:2015
Single resin validation — no need to graft to other tubing materials like silicone for media
filling and sampling applications that involve peristaltic pumps; helps eliminate operator errors
“Extractables” test portfolio available upon request
Included in our Rx-360 Joint Audit Program for Single-Use Systems
Complete validation package available
upon request
Single-Use AdvantaFlex tubing is available with molded mini Tri-Clamp® ends
Single-use Systems can be custom made using AdvantaSil®
platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing.

Discover how much better the right tubing — AdvantaFlex — will work in
your pharmaceutical, biotech, medical, or other critical processing application.

WELD TEST VIDEO

APPLICATIONS

Sterile filling
Vaccine production
Pharmaceutical sampling and delivery systems
Single-use systems
Bioreactor processes
Cell media, harvesting, and fermentation
Pharmaceutical production and processing
High purity water transfer
Filtration

Because of its ability to be sealed and welded, AdvantaFlex is ideal for filling and sampling applications.

SPECIFICATIONS

ADVANTAFLEX® – BIOPHARMACEUTICAL GRADE TPE

Part Number	I.D.		Wall (reference)		O.D.		Working Pressure at 70°F (21.1°C)		Standard Lengths Coiled	Standard Lengths on Spools
	(in.)	(mm.)	(in.)	(mm.)	(in.)	(mm.)	PSI	Bar	(ft.)	(ft.)
APAF-BP-0125-0250	.125	3.18	.062	1.57	.250	6.35	30	2.1	50, 100	500
APAF-BP-0188-0313	.188	4.76	.062	1.57	.313	7.94	23	1.6	50, 100	–
APAF-BP-0188-0375	.188	4.76	.094	2.38	.375	9.52	32	2.2	50, 100	–
APAF-BP-0250-0375	.250	6.35	.063	1.59	.375	9.52	20	1.4	50, 100	–
APAF-BP-0250-0438	.250	6.35	.094	2.38	.438	11.11	23	1.6	50, 100	300
APAF-BP-0250-0500	.250	6.35	.125	3.18	.500	12.70	30	2.1	50	–
APAF-BP-0313-0438	.313	7.94	.062	1.57	.438	11.11	21	1.4	50, 100	300
APAF-BP-0313-0500	.313	7.94	.094	2.38	.500	12.70	24	1.6	50	–
APAF-BP-0375-0500	.375	9.52	.062	1.57	.500	12.70	18	1.3	100	–
APAF-BP-0375-0563	.375	9.52	.094	2.39	.563	14.30	23	1.6	50	–
APAF-BP-0375-0625	.375	9.52	.125	3.18	.625	15.88	24	1.6	50, 100	150
APAF-BP-0500-0750	.500	12.70	.125	3.18	.750	19.09	22	1.5	50, 100	100
APAF-BP-0625-0875	.625	15.88	.125	3.18	.875	22.23	18	1.3	50	–
APAF-BP-0750-1000	.750	19.05	.125	3.18	1.000	25.40	17	1.2	50, 100	75
APAF-BP-0750-1125	.750	19.05	.188	4.76	1.125	28.58	18	1.3	100	–
APAF-BP-1000-1375	1.000	25.40	.188	4.76	1.375	34.93	18	1.3	25	–

Sold by standard lengths only. Add length suffix code to product number when ordering—see the Coil Length Legend at right for length suffix codes. Example: a 50-foot coil of .125 inch I.D. x .250 inch O.D. tubing is product number APAF-BP-0125-0250L. Add length and “S” to denote “spool” for products with lengths available on spools. Example: a 500-foot spool of .125 inch I.D. x .250 inch O.D. tubing is product number APAF-BP-0125-0250-500S. Working pressures are calculated from burst testing using a 3:1 safety factor. Coils and spools are supplied double-bagged in heat-sealed polybags and bulk packed. Contact your AdvantaPure Sales Representative for other packaging options.

The data listed throughout this website is meant only as a guide to aid in design, and is believed to be reliable; however, nothing stated shall constitute a guarantee or warranty for any application. Product field testing should be performed to find the actual values for a specific application.

Coil Length Legend

P = 25 feet L = 50 feet K = 100 feet

PHYSICAL PROPERTIES

Specific Gravity	.89
Durometer, Shore A±5	65
Ultimate Tensile Strength, PSI	1000
Ultimate Enlongation %	550
Tensile Modulus @100%, PSI	410
Tear Strength, Die B, PPI	240
Compression Set, % per ASTM D-395B	25

MOLDED ASSEMBLIES AND CONNECTIONS

Build a complete single-use system from AdvantaFlex
Eliminates the need to splice silicone tubing sections into a process line
Reduce the number of barbed fittings and cable ties needed and their potential for contamination, leaks, and a wasted batch of product
AdvantaFlex molded connections provide a smooth inner surface for even, unrestricted flow
Choose from T’s, Y’s, reducers, couplers, crosses, mini and standard Tri-Clamps®, BioClosure® container closures and inserts such as GL45’s

Available with validated sterility assurance of 10^-6 via gamma irradiation per ISO 11137 method VDmax 25

FILLING ASSEMBLIES

Sterile molded filling assemblies from AdvantaPure continue the shift to Single-Use processes that save time and reduce the risk of cross-contamination while increasing productivity between batches. Manufactured with a focus on quality, the assemblies can be quickly installed and operational in a fraction of the time as compared to traditional systems used in pharmaceutical and biotech filling.

MORE ABOUT MOLDED FILLING ASSEMBLIES

BIOCLOSURE SYSTEM ASSEMBLIES

Standardized configurations for media bottles, flasks, and carboys using AdvantaFlex Biopharmaceutical Grade TPE tubing and molded components are available.

MORE ABOUT BIOCLOSURE SYSTEM ASSEMBLIES

BIOREACTOR TUBING KITS

The Single-Use kits are custom manufactured and assembled from a variety of components — tubing, filters, connectors — to meet your needs. Made from platinum-cured silicone or AdvantaFlex® biopharmaceutical grade TPE tubing, AdvantaPure’s Bioreactor Tubing Kits provide convenience and greater efficiency.

MORE ABOUT BIOREACTOR TUBING KITS