AdvantaFlex addresses the
need for a flexible, translucent, sterilizable, moldable, heat-sealable, and weldable biopharmaceutical
tubing for fluid processing. AdvantaFlex TPE tubing maintains its physical properties following
sterilization processes, resists kinking, remains translucent for visible product flow, and does not become gummy.
Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab.
KEY FEATURES
- Sterile weldable and heat sealable
- Available as leak-proof molded connections and
tubing - Made from FDA-approved ingredients
- Certified free of silicone oils and animal-derived ingredients
- Sterilizable by autoclave or gamma radiation
- Available with validated sterility assurance of 10-6 via gamma irradiation
per ISO 11137 method VDmax 25 - Meets various ISO and USP standards, including Class VI
- Meets European Pharmacopoeia 3.2.9 standards
- REACH, RoHS, and California Proposition 65 compliant
- Excellent low absorption and adsorption characteristics as compared to silicone
- Low permeability as compared to silicone
- Smooth interior for excellent flow and performance
- Translucent for fluid flow visibility
- Excellent tubing component for Single-Use systems
- Sizes from 1/8″ (.125) through 1″ (1.000) I.D.
- Custom lengths, sizes, and packaging available
- Supplied double bagged; sealed in polybags at manufacture for cleanliness
- Documented lot traceable with identification on packaging
- Documented quality control per ISO 9001:2015
- Single resin validation — no need to graft to other tubing materials like silicone for media
filling and sampling applications that involve peristaltic pumps; helps eliminate operator errors - “Extractables” test portfolio available upon request
- Included in our Rx-360 Joint Audit Program for Single-Use Systems
- Complete validation package available
upon request - Also available as sealed tubing ends
- Single-Use AdvantaFlex tubing is available with molded mini Tri-Clamp® ends
- Single-use Systems can be custom made using AdvantaSil®
platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing.
Discover how much better the right tubing — AdvantaFlex — will work in
your pharmaceutical, biotech, medical, or other critical processing application.
WELD TEST VIDEO
APPLICATIONS
Sterile
filling- Vaccine production
- Pharmaceutical sampling and delivery systems
- Single-use systems
- Bioreactor processes
- Cell media, harvesting, and fermentation
- Pharmaceutical production and processing
- High purity water transfer
- Filtration
Because of its ability to be sealed and welded, AdvantaFlex is ideal for filling and
sampling applications.
SPECIFICATIONS

ADVANTAFLEX® – BIOPHARMACEUTICAL GRADE TPE
Part Number |
I.D. |
Wall (reference) |
O.D. |
Working Pressure at 70°F (21.1°C) |
Standard Lengths Coiled |
Standard Lengths on Spools |
||||
(in.) | (mm.) | (in.) | (mm.) | (in.) | (mm.) | PSI | Bar | (ft.) | (ft.) | |
APAF-BP-0125-0250 | .125 | 3.18 | .062 | 1.57 | .250 | 6.35 | 30 | 2.1 | 50, 100 | 500 |
APAF-BP-0188-0313 | .188 | 4.76 | .062 | 1.57 | .313 | 7.94 | 23 | 1.6 | 50, 100 | – |
APAF-BP-0188-0375 | .188 | 4.76 | .094 | 2.38 | .375 | 9.52 | 32 | 2.2 | 50, 100 | – |
APAF-BP-0250-0375 | .250 | 6.35 | .063 | 1.59 | .375 | 9.52 | 20 | 1.4 | 50, 100 | – |
APAF-BP-0250-0438 | .250 | 6.35 | .094 | 2.38 | .438 | 11.11 | 23 | 1.6 | 50, 100 | 300 |
APAF-BP-0250-0500 | .250 | 6.35 | .125 | 3.18 | .500 | 12.70 | 30 | 2.1 | 50 | – |
APAF-BP-0313-0438 | .313 | 7.94 | .062 | 1.57 | .438 | 11.11 | 21 | 1.4 | 50, 100 | 300 |
APAF-BP-0313-0500 | .313 | 7.94 | .094 | 2.38 | .500 | 12.70 | 24 | 1.6 | 50 | – |
APAF-BP-0375-0500 | .375 | 9.52 | .062 | 1.57 | .500 | 12.70 | 18 | 1.3 | 100 | – |
APAF-BP-0375-0563 | .375 | 9.52 | .094 | 2.39 | .563 | 14.30 | 23 | 1.6 | 50 | – |
APAF-BP-0375-0625 | .375 | 9.52 | .125 | 3.18 | .625 | 15.88 | 24 | 1.6 | 50, 100 | 150 |
APAF-BP-0500-0750 | .500 | 12.70 | .125 | 3.18 | .750 | 19.09 | 22 | 1.5 | 50, 100 | 100 |
APAF-BP-0625-0875 | .625 | 15.88 | .125 | 3.18 | .875 | 22.23 | 18 | 1.3 | 50 | – |
APAF-BP-0750-1000 | .750 | 19.05 | .125 | 3.18 | 1.000 | 25.40 | 17 | 1.2 | 50, 100 | 75 |
APAF-BP-0750-1125 | .750 | 19.05 | .188 | 4.76 | 1.125 | 28.58 | 18 | 1.3 | 100 | – |
APAF-BP-1000-1375 | 1.000 | 25.40 | .188 | 4.76 | 1.375 | 34.93 | 18 | 1.3 | 25 | – |
Sold by standard lengths only. Add length suffix code to product number when The data listed throughout this website is meant only as a guide to aid in design, and |
Coil Length Legend
P = 25 feet
L = 50 feet
K = 100 feet
PHYSICAL PROPERTIES
Specific Gravity | .89 |
Durometer, Shore A±5 | 65 |
Ultimate Tensile Strength, PSI | 1000 |
Ultimate Enlongation % | 550 |
Tensile Modulus @100%, PSI | 410 |
Tear Strength, Die B, PPI | 240 |
Compression Set, % per ASTM D-395B |
25 |
Max. Operating Temperature, °F | 275 |
Brittle Temperature, °F | -88 |
MOLDED ASSEMBLIES AND CONNECTIONS
Build a complete single-use system from AdvantaFlex
- Eliminates the need to splice silicone tubing sections into a process line
- Reduce the number of barbed fittings and cable ties needed and their potential for
contamination, leaks, and a wasted batch of product - AdvantaFlex molded
connections provide a smooth inner surface for even, unrestricted flow - Choose from T’s, Y’s, reducers, couplers, crosses, mini and standard Tri-Clamps®,
BioClosure® container closures and
inserts such as GL45’s
- Available with validated sterility assurance of 10-6 via gamma
irradiation per ISO 11137 method VDmax 25
FILLING ASSEMBLIES
Sterile molded filling assemblies from AdvantaPure continue the shift to
Single-Use processes that save time and reduce the risk of cross-contamination while increasing productivity
between batches. Manufactured with a focus on quality, the assemblies can be quickly installed and operational in
a fraction of the time as compared to traditional systems used in pharmaceutical and biotech filling.
MORE ABOUT MOLDED FILLING ASSEMBLIES
BIOCLOSURE
SYSTEM ASSEMBLIES
Standardized configurations for
media bottles, flasks, and carboys using AdvantaFlex Biopharmaceutical Grade TPE tubing and molded components are
available.
MORE ABOUT BIOCLOSURE SYSTEM
ASSEMBLIES
BIOREACTOR TUBING KITS
The Single-Use kits are custom manufactured and assembled from a variety of components —
tubing, filters, connectors — to meet your needs. Made from platinum-cured silicone or
AdvantaFlex® biopharmaceutical grade TPE tubing, AdvantaPure’s Bioreactor Tubing Kits
provide convenience and greater efficiency.
MORE ABOUT BIOREACTOR TUBING
KITS
Download a printable version of our AdvantaFlex brochure.
AdvantaFlex.pdf
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