Advantaflex

Validations RequestAdvantaFlex LogoAdvantaFlex®: Biopharmaceutical Grade TPE Tubing

Sterile Weldable, Heat Sealable Bioprocess Tubing

high pressure burst testhigh pressure burst testAdvantaFlex addresses the
need for a flexible, translucent, sterilizable, moldable, heat-sealable, and weldable biopharmaceutical
tubing for fluid processing. AdvantaFlex TPE tubing maintains its physical properties following
sterilization processes, resists kinking, remains translucent for visible product flow, and does not become gummy.
Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab.

KEY FEATURES

  • Sterile weldable and heat sealable
  • Available as leak-proof molded connections and
    tubing
  • Made from FDA-approved ingredients
  • Certified free of silicone oils and animal-derived ingredients
  • Sterilizable by autoclave or gamma radiation
  • Available with validated sterility assurance of 10-6 via gamma irradiation
    per ISO 11137 method VDmax 25
  • Meets various ISO and USP standards, including Class VI
  • Meets European Pharmacopoeia 3.2.9 standards
  • REACH, RoHS, and California Proposition 65 compliant
  • Excellent low absorption and adsorption characteristics as compared to silicone
  • Low permeability as compared to silicone
  • Smooth interior for excellent flow and performance
  • Translucent for fluid flow visibility
  • Excellent tubing component for Single-Use systems
  • Sizes from 1/8″ (.125) through 1″ (1.000) I.D.
  • Custom lengths, sizes, and packaging available
  • Supplied double bagged; sealed in polybags at manufacture for cleanliness
  • Documented lot traceable with identification on packaging
  • Documented quality control per ISO 9001:2015
  • Single resin validation — no need to graft to other tubing materials like silicone for media
    filling and sampling applications that involve peristaltic pumps; helps eliminate operator errors
  • “Extractables” test portfolio available upon request
  • Included in our Rx-360 Joint Audit Program for Single-Use Systems
  • Complete validation package available
    upon request
  • Also available as sealed tubing ends
  • Single-Use AdvantaFlex tubing is available with molded mini Tri-Clamp® ends
  • Single-use Systems can be custom made using AdvantaSil®
    platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing.

There is a Better Alternative
Discover how much better the right tubing — AdvantaFlex — will work in
your pharmaceutical, biotech, medical, or other critical processing application.

AdvantaFlex Weld Strength

WELD TEST VIDEO

APPLICATIONS

  • AdvantaFlex with bagsSterile
    filling
  • Vaccine production
  • Pharmaceutical sampling and delivery systems
  • Single-use systems
  • Bioreactor processes
  • Cell media, harvesting, and fermentation
  • Pharmaceutical production and processing
  • High purity water transfer
  • Filtration

Because of its ability to be sealed and welded, AdvantaFlex is ideal for filling and
sampling applications.

SPECIFICATIONS

AdvantaFlex Biopharmaceutical TPE tubing

ADVANTAFLEX® – BIOPHARMACEUTICAL GRADE TPE

Part
Number 		I.D.
 Wall
(reference)
 O.D.
 Working
Pressure
at 70°F (21.1°C)		 Standard Lengths
Coiled
 Standard Lengths
on Spools
  (in.) (mm.) (in.) (mm.) (in.) (mm.) PSI Bar (ft.) (ft.)
APAF-BP-0125-0250 .125 3.18 .062 1.57 .250 6.35 30 2.1 50, 100 500
APAF-BP-0188-0313 .188 4.76 .062 1.57 .313 7.94 23 1.6 50, 100 –
APAF-BP-0188-0375 .188 4.76 .094 2.38 .375 9.52 32 2.2 50, 100 –
APAF-BP-0250-0375 .250 6.35 .063 1.59 .375 9.52 20 1.4 50, 100 –
APAF-BP-0250-0438 .250 6.35 .094 2.38 .438 11.11 23 1.6 50, 100 300
APAF-BP-0250-0500 .250 6.35 .125 3.18 .500 12.70 30 2.1 50 –
APAF-BP-0313-0438 .313 7.94 .062 1.57 .438 11.11 21 1.4 50, 100 300
APAF-BP-0313-0500 .313 7.94 .094 2.38 .500 12.70 24 1.6 50 –
APAF-BP-0375-0500 .375 9.52 .062 1.57 .500 12.70 18 1.3 100 –
APAF-BP-0375-0563 .375 9.52 .094 2.39 .563 14.30 23 1.6 50 –
APAF-BP-0375-0625 .375 9.52 .125 3.18 .625 15.88 24 1.6 50, 100 150
APAF-BP-0500-0750 .500 12.70 .125 3.18 .750 19.09 22 1.5 50, 100 100
APAF-BP-0625-0875 .625 15.88 .125 3.18 .875 22.23 18 1.3 50 –
APAF-BP-0750-1000 .750 19.05 .125 3.18 1.000 25.40 17 1.2 50, 100 75
APAF-BP-0750-1125 .750 19.05 .188 4.76 1.125 28.58 18 1.3 100 –
APAF-BP-1000-1375 1.000 25.40 .188 4.76 1.375 34.93 18 1.3 25 –

Sold by standard lengths only. Add length suffix code to product number when
ordering—see the Coil Length Legend at right for length suffix codes. Example: a 50-foot coil of .125 inch
I.D. x .250 inch O.D. tubing is product number APAF-BP-0125-0250L. Add length and “S” to denote “spool”
for products with lengths available on spools. Example: a 500-foot spool of .125 inch I.D. x .250 inch
O.D. tubing is product number APAF-BP-0125-0250-500S. Working pressures are calculated from burst testing
using a 3:1 safety factor. Coils and spools are supplied double-bagged in heat-sealed polybags and bulk
packed. Contact your AdvantaPure Sales Representative for other packaging options.

The data listed throughout this website is meant only as a guide to aid in design, and
is believed to be reliable; however, nothing stated shall constitute a guarantee or warranty for any
application. Product field testing should be performed to find the actual values for a specific
application.

Coil Length Legend

P = 25 feet
L = 50 feet
K = 100 feet

PHYSICAL PROPERTIES

Specific Gravity .89
Durometer, Shore A±5 65
Ultimate Tensile Strength, PSI 1000
Ultimate Enlongation % 550
Tensile Modulus @100%, PSI 410
Tear Strength, Die B, PPI 240
Compression Set, % per ASTM D-395B
 25
Max. Operating Temperature, °F 275
Brittle Temperature, °F -88

MOLDED ASSEMBLIES AND CONNECTIONS

  • AdvantaFlex molded connectionsAdvantaFlex MoldedBuild a complete single-use system from AdvantaFlex
  • Eliminates the need to splice silicone tubing sections into a process line
  • Reduce the number of barbed fittings and cable ties needed and their potential for
    contamination, leaks, and a wasted batch of product
  • AdvantaFlex molded
    connections     provide a smooth inner surface for even, unrestricted flow
  • Choose from T’s, Y’s, reducers, couplers, crosses, mini and standard Tri-Clamps®,
    BioClosure® container closures and
    inserts such as GL45’s

  • Available with validated sterility assurance of 10-6 via gamma
    irradiation per ISO 11137 method VDmax 25

filling assembliesFILLING ASSEMBLIES

Sterile molded filling assemblies from AdvantaPure continue the shift to
Single-Use processes that save time and reduce the risk of cross-contamination while increasing productivity
between batches. Manufactured with a focus on quality, the assemblies can be quickly installed and operational in
a fraction of the time as compared to traditional systems used in pharmaceutical and biotech filling.

MORE ABOUT MOLDED FILLING ASSEMBLIES

BIOCLOSURE SYSTEM ASSEMBLIESBIOCLOSURE
SYSTEM ASSEMBLIES

animal derived indgediantsStandardized configurations for
media bottles, flasks, and carboys using AdvantaFlex Biopharmaceutical Grade TPE tubing and molded components are
available.

MORE ABOUT BIOCLOSURE SYSTEM
ASSEMBLIES

bioreactor tubingBIOREACTOR TUBING KITS

The Single-Use kits are custom manufactured and assembled from a variety of components —
tubing, filters, connectors — to meet your needs. Made from platinum-cured silicone or
AdvantaFlex® biopharmaceutical grade TPE tubing, AdvantaPure’s Bioreactor Tubing Kits
provide convenience and greater efficiency.

MORE ABOUT BIOREACTOR TUBING
KITS

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