Made in USA
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DocuLink™ - Manifold Identification System
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DocuLink is our new silicone manifold identification system providing individual identification and tracking information directly on each manifold in the form of a silicone-encased label. Manifold information can be linked to an on-line data management site to provide easy document retrieval for audits and validations. READ MORE...
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BioClosure™ Systems
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BioClosure high purity container closures work with vessels of glass, metal, or plastic. Stoppers, caps, True Unions, GL45’s, and other styles, with or without tubing inserts, are available. READ MORE...
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GammaTag® - An Option For Process Equipment Tracking Systems
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GammaTag is our new gamma-radiation-resistant RFID tag which can be used as part of a Process Equipment Tracking System for Single-Use Sterile Batch Filling Assemblies and other high purity process components. READ MORE...
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Gamma Irradiation Services
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Have your single use system gamma irradiated before it arrives at your location and save the additional inventorying, transportation costs, and transit time.
Bagged and labeled products are picked up from AdvantaPure’s facility and conveyed to a local gamma irradiation service provider. Using Cobalt 60 radiation, microorganisms and bacteria are destroyed while your single use system remains in its original packaging. Products are then returned to AdvantaPure for final inspection and shipment to your location.
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Eliminate production stoppages for sterilization, reduce the risk of contamination, and increase efficiency by incorporating single use systems from AdvantaPure. Single use systems, or SUS, simplify cleaning validations—use once and discard.
Each system is custom made using platinum-cured, Class VI silicone tubing and hose or Class VI biopharmaceutical grade tubing for peristaltic pump applications. Add fittings, stoppers and container closures, filters, bags, bottles, labels and tracking options, and other components.
Single use systems are not intended for implantation or continuous steam applications.
Key Features
- Custom manufactured and assembled from a variety of components
- Reduces end-user assembly labor expense and time
- Reduces cross contamination risks
- Saves energy and resource costs by eliminating cleaning
- Reduces production downtime by eliminating certain cleaning validation requirements
- Provides flexibility and speed in facility design—system redesigns are implemented faster than with hard piping
- Less costly process development and design compared to systems of hard piping
- Manufactured and packaged in a Class 7 (Class 10,000) ISO-certified clean room
- Gamma irradiation services available
- Documented lot traceable with identification on bags
- Documented quality control
- Experienced engineers available for technical assistance
- Silicone tubing and molded connections provide a single, animal-derivedingredient-free material contact surface
- Optional RFID tags easily attach to assemblies for identification purposes—provide reliable electronic data storage and current status of assemblies from inception to disposal
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VIDEO
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Single Use Products:
Tubing Sets vs Molded Manifolds |
| Pharmamanufacturing.com recently interviewed our Director of Product Development, John Stover, about single-use systems.
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Build Your System From...
| Silicone Tubing & Hose |
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 Low-volatile grade, platinum-cured silicone tubing and braid-reinforced silicone hose is clean-room manufactured by AdvantaPure for pharmaceutical and biotech applications.
Both the tubing (called APST) and hose (APSH) have undergone extensive physical, chemical, and biological testing and meet USP Class VI, FDA CFR 177.2600, ISO 10993, European Pharmacopoeia 3.1.9, and 3A standards.
APST size range: .030” through 1” I.D. (.76mm through 25.40mm I.D.)
APSH size range: .063” through 1” I.D. (1.59mm through 25.40mm I.D.)
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| AdvantaFlex® BioPharmaceutical Grade Tubing |
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 AdvantaFlex addresses the need for a flexible, translucent, sterilizable, heat sealable, and weldable biopharmaceutical tubing for fluid processing. The unique properties of AdvantaFlex help it outlast similar tubing tested in peristaltic pumps by 6-10 times.
AdvantaFlex is ideal for aseptic tubing welds, as it eliminates costly aseptic connectors and multiple contact surfaces. The tubing is made from FDA-approved ingredients and meets various ISO and USP standards, including Class VI, as well as European Pharmacopoeia 3.2.2.1 standards.
Size range: 1/8” to 1” I.D. (3.18mm to 25.40mm I.D.)
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Build Your System From...
| Molded Silicone Manifolds |
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 Single-use molded silicone manifolds provide a seamless transition between tubing and connections for a continuous, leak-proof flow. Molded connections include Y, T, cross, reducer, Tri-Clamp®, and mini Tri-Clamp styles. Made from platinum-cured silicone, they allow for one material contact surface throughout the system. Connections sizes differ depending on style.
Size range: .188” to 1” I.D. (4.76mm to 25.40mm I.D.)
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Build Your System From...
| Connections |
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 Barbed Fittings
come in Y, T, elbow, and reducer styles. Materials include polypropylene, polyethylene, and PVDF.
Size range: 1/8” to 1” hose I.D. (3.18mm to 25.40mm hose I.D.)
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 Overmolded Ends
are available in Tri-Clamp and mini Tri-Clamp styles in Hytrel® and polypropylene materials.
Size range: 1/8” to 1-3/16” hose I.D. (3.18mm to 30.16mm hose I.D.)
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 Aseptic Connectors
reduce contamination risks and keep processing systems pure. Several easy-touse styles are available.
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 Quick Connects
offer on-the-spot connections and come in several materials. Dependable and secure.
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| Clamps |
 Pinch Clamps
of polypropylene or polyester squeeze tubing closed anywhere along a line. One piece construction.
Sizes fit up to 3/4” tubing O.D. (19.05mm tubing O.D.)
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 Tri-Clamp Connection Clamps
come in 304 stainless steel and durable plastic.
Size range: 1/2” to 4” (12.70mm to 101.60mm), depending on material
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| Filters |
Bags |
Bottles |
 Choose from a variety of styles, sizes, and manufacturers for your single use system. |
 AdvantaPure can supply bags from a number of leading manufacturers. Let us know what you need. |
 Laboratory and sampling bottles can also be incorporated into your system. Select from HPDE and other materials. For stoppers and container closures, see BioClosure™ Systems below. |
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Build Your System From...
| BioClosure™ Systems - High Purity Container Closures |
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Bottle Stoppers and stopper assemblies are manufactured from platinum-cured, Class VI silicone and are available solid, with holes, and with tubing inserts. They can easily become part of your manifold design for batch processing in a variety of sampling and storage containers made from glass, plastics, or metal.
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| Experienced engineers with 20 years of knowledge in silicone extrusion and molding are available for technical assistance.
Contact your AdvantaPure representative today to see how Single-Use Process Systems can solve your needs: 1-888-755-4370
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Click link to download a printable version of our Single-Use Process Systems brochure. 