AdvantaBio® EcoFlex™ APEF-BP Biopharmaceutical Grade TPE Tubing
EcoFlex™ is AdvantaPure’s newest translucent thermoplastic elastomer (TPE) single-use tubing, engineered to support sustainable biopharmaceutical and pharmaceutical manufacturing applications. Based on the proven formulation of AdvantaPure’s flagship AdvantaFlex® APAF TPE tubing, EcoFlex delivers the same trusted performance, flexibility, and durability required for critical single-use processes. By replacing a traditional fossil-based oil with a bio-based oil in the polymer formulation, EcoFlex enhances product sustainability while maintaining the consistent performance, quality, and reliability demanded in regulated environments.
A sealable and weldable product, EcofFlex is suited to a wide range of applications. For current AdvantaFlex APAF users, EcoFlex provides a more sustainable product providing a reduction of product carbon footprint by approximately 15% with no changes to form, fit, function, manufacturing process, specifications, or regulatory testing compliance.
Key Features & Benefits
- High-quality aseptic sealing disconnection
- High strength, quality aseptic welded connections
- Low absorption and good chemical resistance
- Translucent for fluid flow visibility
- Free of silicone oils
- Wide range of standard sizes from 0.125” (3.175 mm) through 1” (25.4 mm) I.D.
- Available as leak-proof overmolded connections
- Custom lengths, sizes, and packaging available
- Security of supply with redundant manufacturing
- Manufactured with a focus on sustainability
- Comprehensive validation package to expedite qualification and validation
Product Specifications
Measurements
| Part Number | I.D. | Wall | O.D. | Working Pressure 3:1 Safety Factor 70°F (21.1°C) | Bend Radius | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| in | mm | in | mm | in | mm | PSI | Bar | in | mm | |
| A7530020 | 0.125 | 3.18 | 0.063 | 1.60 | 0.250 | 6.35 | 30 | 2.1 | 0.250 | 6.35 |
| A7530046 | 0.188 | 4.78 | 0.094 | 2.38 | 0.375 | 9.52 | 32 | 2.2 | 0.375 | 9.53 |
| A7530059 | 0.250 | 6.35 | 0.063 | 1.59 | 0.375 | 9.52 | 20 | 1.4 | 0.688 | 17.47 |
| A7530072 | 0.250 | 6.35 | 0.094 | 2.38 | 0.438 | 11.11 | 23 | 1.6 | 0.583 | 14.81 |
| A7530085 | 0.250 | 6.35 | 0.125 | 3.18 | 0.500 | 12.70 | 30 | 2.1 | 0.521 | 13.23 |
| A7530137 | 0.375 | 9.52 | 0.125 | 3.18 | 0.625 | 15.88 | 24 | 1.6 | 0.917 | 23.29 |
| A7530163 | 0.500 | 12.70 | 0.125 | 3.18 | 0.750 | 19.09 | 22 | 1.5 | 1.417 | 35.99 |
| A7530189 | 0.750 | 19.05 | 0.125 | 3.18 | 1.000 | 25.40 | 17 | 1.2 | 3.250 | 82.55 |
NOTE: Not all standard part numbers are stocked items. For the up-to-date list of stocked sizes and lengths available, please contact your sales representative.
Non-listed sizes and custom lengths are available by special order. Coils are supplied double bagged in heat-sealed polybags and bulk packed. Contact your AdvantaPure sales representative for other packaging options.
NOTE: The data listed throughout this datasheet is meant only as a guide to aid in the design and is believed to be reliable; however, nothing stated shall constitute a guarantee or warranty for any application. Product field testing should be performed to find the actual values for a specific application.
Physical Properties
| ASTM Method | Value | |
|---|---|---|
| Durometer, Shore A | D2240 | 65 |
| Specific Gravity | D792 | 0.89 |
| Ultimate Tensile, psi (MPa) | D412 | 1000 (6.89) |
| Ultimate Elongation, % | D412 | 550 |
| Tensile Modulus 100%, psi (MPa) | D412 | 410 (2.83) |
| Tensile Modulus 300%, psi (MPa) | D412 | 640 (4.41) |
| Tear Strength, Die B, ppi (kN/M) | D624 | 240 (42.0) |
| Compression Set, % | D395B | 25 |
Chemical Compatibility
| Acids, Dilute / Weak | Acceptable |
| Acids, Strong / Concentrated | Acceptable |
| Bases, Dilute / Weak | Acceptable |
| Bases, Strong / Concentrated | Acceptable |
| Salts | Acceptable |
| High Purity Water | Acceptable |
| Oil/Water Emulsion | Test Before Use |
| Alcohol | Not Recommended* |
| Organic Solvent | Not Recommended |
Sterility
Available with validated sterility assurance of 10-6 via
gamma irradiation per ISO 11137 method VDmax 25. A full
sterility validation guide is available upon request.
Sterilization Methods
| Autoclave | One-time cycle at 121°C, 30 min |
| Gamma Irradiation | One-time up to 40 kGy |
| X-Ray | One-time up to 40 kGy |
Typical Applications
Aseptic welding connections
Aseptic sealing disconnection
Single-use fluid transfer sets
Biopharmaceutical production, sampling and delivery systems
Cell media, harvesting, and fermentation
Buffer and media preparation
Ideal for use in assembles and bag manifolds
Filtration
Suggested Additional Components
Molded Tubing
Ends
Ideal for aseptic transfer and processing, overmolded with multi-port sanitary clamp and ends to form a smooth fluid path.
Overmolding - Connections and Assemblies
AdvantaSil APSPG-MAX sizes can be integrated into our assemblies and manifolds. Choose from standard available wyes, tees, sanitary ends, crosses, and reducers, or opt for our custom overmolding design services to create custom pieces for your unique application.
Tubing Kits
Built-to-order in an ISO Class 7 cleanroom, assembled with various components for convenience and efficiency.
Sterile Bottle Assemblies
Provide a ready-to-use, cost-effective solution for aseptic
sampling, cell growth, and filling applications. The robust molded BioClosure® is designed for storage and containment.