Phone: 1-888-755-4370 (toll free US only)
Phone: 1-215-526-2151 (worldwide)
Single-use molded manifolds are custom made to meet your batch filling and sampling needs in drug and vaccine production.
Manufactured from AdvantaFlex® biopharmaceutical grade TPE or platinum-cured Class VI silicone, molded manifolds eliminate the need for barbed fittings while providing a seamless transition from tubing to connection for a continuous, unrestricted flow. Designs range from simple molded sanitary ends to complex configurations with varying lengths of tubing and several molded connections.
Single use molded manifolds are not intended for implantation or continuous steam applications.
|This example of an assembly made from tubing and barbed fittings is comprised of nine separate pieces of tubing of varying sizes and lengths, plus four fittings that require insertion into the tubing at three points each, with double cable ties installed at each connection for secure attachment.||An AdvantaPure Single-Use Process System is a complete unit, packaged in a sealed polybag and ready for use. Leaks, entrapment, and contamination concerns involved with barbed fitting connections are eliminated. Labor, numerous inventories, and time to assemble the manifold is unnecessary.|
|This illustration of a tubing set assembly using barbed fittings shows how the edge of a fitting may disrupt the flow or create an area of entrapment and potential leakage. Additionally, cable ties used to secure barbed fittings have the potential to pierce bags and packaging.||The interior of a one-piece molded manifold connection provides a smooth inner sur- face and a seamless transition for a continuous, unrestricted, leak-proof flow. Molded manifolds reduce the risk of a wasted batch of costly pharmaceutical product.|
Single-use Molded Manifolds provide a seamless transition between tubing and connections for a continuous, leak-proof flow. Molded connections include Y, T, cross, reducer, Tri-Clamp®, and mini Tri-Clamp styles. Made from platinum-cured silicone or AdvantaFlex biopharmaceutical grade TPE, they allow for one material contact surface throughout the system. Connections sizes differ depending on style.
Size range: .188" to 1" I.D. (4.76mm to 25.40mm I.D.)
Low-volatile grade, platinum-cured silicone tubing is clean-room produced and has undergone extensive physical, chemical, and biological testing. Called APST, it meets many USP standards, including Class VI, as well as FDA, ISO, European Pharmacopoeia, and 3A standards. APST offers a complete validation package and is stocked in fifty sizes.
Size range: .030" through 1" I.D. (.76mm through 25.40mm I.D.)
AdvantaFlex addresses the need for a flexible, translucent, sterilizable, heat sealable, weldable and moldable biopharmaceutical tubing for fluid processing. The unique properties of AdvantaFlex help it outlast similar tubing tested in peristaltic pumps by 6-10 times.
AdvantaFlex is ideal for aseptic tubing welds, as it eliminates costly aseptic connectors and multiple contact surfaces. The tubing is made from FDA-approved ingredients and meets various ISO and USP standards, including Class VI, as well as European Pharmacopoeia 22.214.171.124 standards.
Size range: 1/8" to 1" I.D. (3.18mm to 25.40mm I.D.)
AdvantaFlex tubing can be molded onto aseptic connectors and filters (patent pending), reducing the risk of leaks associated with barbed fittings and eliminating cable ties and their risk of piercing bags or packaging.
Note: Molding onto aseptic connectors and filters may involve R&D and lengthy lead times; call for details.
Attach Your Manifold System to a Variety of Sampling and Storage Containers With:
AdvantaPure's BioClosure Systems offer purity, secure seals, and versatility in design. Stoppers, caps, True Union and GL45 inserts, and other styles, available with or without tubing inserts, are manufactured from platinum-cured, Class VI silicone or AdvantaFlex biopharmaceutical TPE.
If you're not sure that molded manifolds are right for your application, let us manufacture your tubing sets. Assembled in Class 7, ISO- certified clean rooms, they're fabricated from tubing, fittings, and accessories that you specify, such as filters, aseptic connectors, bottles, and bags.
Contact your AdvantaPure sales representative for information.
Experienced engineers with 20 years of knowledge in silicone extrusion and molding are available for technical assistance. Contact your AdvantaPure representative today to see how Single-Use Molded Silicone Manifolds can solve your needs: 1-888-755-4370
Download a printable version of our Single-Use Molded Manifolds brochure. Single_Use_Manifolds.pdf (476KB)
The cutaway view above of a molded Y connector shows the smooth interior created by the molding process.
This cutaway of a plastic barbed Y fitting shows the potential areas of flow disruption and entrapment created by the barbs.
DocuLink is our new silicone manifold identification system providing individual identification and tracking information directly on each manifold in the form of a silicone-encased label. Manifold information can be linked to an on-line data management site to provide easy document retrieval for audits and validations. READ MORE...
Have your single use system gamma irradiated before it arrives at your location and save the additional inventorying, transportation costs, and transit time.
Bagged and labeled products are picked up from AdvantaPure's facility and conveyed to a local gamma irradiation service provider. Using Cobalt 60 radiation, microorganisms and bacteria are destroyed while your single use system remains in its original packaging. Products are then returned to AdvantaPure for final inspection and shipment to your location.
A number of AdvantaPure's silicone and AdvantaFlex products, particularly those designed for single use, are available with validated sterility assurance of 10-6 per ISO 11137 method VDmax. Contact us for more information at 1-888-755-4370.